A Rapid, Reversible, and Tunable Method to Regulate Protein Function in Living Cells Using Synthetic Small Molecules

Rapid and reversible methods for perturbing the function of specific proteins are desirable tools for probing complex biological systems. We have developed a general technique to regulate the stability of specific proteins in mammalian cells using cell-permeable, synthetic molecules. We engineered m...

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Hauptverfasser: Banaszynski, Laura A., Chen, Ling-chun, Maynard-Smith, Lystranne A., Lisa Ooi, A. G., Wandless, Thomas J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290523/
https://ncbi.nlm.nih.gov/pubmed/16959577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.07.025
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