The PPAR Gamma Agonist Troglitazone Regulates Erk 1/2 Phosphorylation via a PPARγ-Independent, MEK-Dependent Pathway in Human Prostate Cancer Cells

Thiazolidinediones (TZDs) dramatically reduce the growth of human prostate cancer cells in vitro and in vivo. To determine whether the antitumor effects of TZDs were due in part to changes in the MEK/Erk signaling pathway, we examined the regulation of Erk phosphorylation by the TZD troglitazone wit...

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Main Authors: Bolden, Adrienne, Bernard, Lynikka, Jones, Danielle, Akinyeke, Tunde, Stewart, LaMonica V.
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289875/
https://ncbi.nlm.nih.gov/pubmed/22448169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/929052
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