p53 Regulates Cell Cycle and MicroRNAs to Promote Differentiation of Human Embryonic Stem Cells

Multiple studies show that tumor suppressor p53 is a barrier to dedifferentiation; whether this is strictly due to repression of proliferation remains a subject of debate. Here, we show that p53 plays an active role in promoting differentiation of human embryonic stem cells (hESCs) and opposing self...

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Autores principales: Jain, Abhinav K., Allton, Kendra, Iacovino, Michelina, Mahen, Elisabeth, Milczarek, Robert J., Zwaka, Thomas P., Kyba, Michael, Barton, Michelle Craig
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289600/
https://ncbi.nlm.nih.gov/pubmed/22389628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001268
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