Transient muscle paralysis degrades bone via rapid osteoclastogenesis

A unilateral injection of botulinum toxin A (BTxA) in the calf induces paralysis and profound loss of ipsalateral trabecular bone within days. However, the cellular mechanism underlying acute muscle paralysis-induced bone loss (MPIBL) is poorly understood. We hypothesized that MPIBL arises via rapid...

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Detalhes bibliográficos
Main Authors: Aliprantis, Antonios O., Stolina, Marina, Kostenuik, Paul J., Poliachik, Sandra L., Warner, Sarah E., Bain, Steven D., Gross, Ted S.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2012
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289507/
https://ncbi.nlm.nih.gov/pubmed/22125315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-196642
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