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Src inhibitors in the treatment of metastatic bone disease: rationale and clinical data
Src is a nonreceptor tyrosine kinase essential for the activation of osteoclasts, the cells that degrade bone. Src also regulates normal cell functions, cancer cell growth and metastasis to organs, including bone where tumor cells induce bone destruction by osteoclasts. Src inhibitors prevent bone d...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3289094/ https://ncbi.nlm.nih.gov/pubmed/22384312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/cli.11.150 |
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