Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores

The engagement of antigen receptors on lymphocytes leads to the activation of phospholipase C-γ, the mobilization of intracellular calcium and the activation of the NFAT transcription factor. The coupling of antigen receptors to the activation of NFAT is modulated by numerous cellular effectors incl...

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Detalhes bibliográficos
Main Authors: Martin, Victoria A., Wang, Wen-Horng, Lipchik, Andrew M., Parker, Laurie L., He, Yantao, Zhang, Sheng, Zhang, Zhong-Yin, Geahlen, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289042/
https://ncbi.nlm.nih.gov/pubmed/22261254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2012.01.001
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