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Comparison of Electrophysiological and Antiarrhythmic Effects of Vernakalant, Ranolazine, and Sotalol in Canine Pulmonary Vein Sleeve Preparations

INTRODUCTION: Vernakalant (VER) is a relatively atrial-selective antiarrhythmic drug capable of blocking potassium and sodium currents in a frequency- and voltage-dependent manner. Ranolazine (RAN) is a sodium channel blocker shown to exert antiarrhythmic effects in pulmonary vein (PV) sleeves. DL-s...

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Detalhes bibliográficos
Main Authors: Sicouri, Serge, Pourrier, Marc, Gibson, John K., Lynch, Joseph J., Antzelevitch, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288874/
https://ncbi.nlm.nih.gov/pubmed/22019863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2011.10.021
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