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DNA-responsive inflammasomes and their regulators in autoimmunity
Upon sensing microbial and self-derived DNA, DNA sensors initiate innate immune responses. These sensors include the interferon (IFN)-inducible Toll-like receptor 9 (TLR9) and PYHIN proteins. Upon sensing DNA, cytosolic (murine Aim2 and human AIM2) and nuclear (IFI16) PYHIN proteins recruit an adapt...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3288811/ https://ncbi.nlm.nih.gov/pubmed/22245264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2011.12.007 |
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