Spironolactone and colitis: Increased mortality in rodents and in humans

BACKGROUND AND METHODS: Crohn’s disease causes intestinal inflammation leading to intestinal fibrosis. Spironolactone is an anti-fibrotic medication commonly used in heart failure to reduce mortality. We examined whether spironolactone is anti-fibrotic in the context of intestinal inflammation. In v...

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Hlavní autoři: Johnson, Laura A., Govani, Shail M., Joyce, Joel C., Waljee, Akbar K., Gillespie, Brenda W., Higgins, Peter D. R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288762/
https://ncbi.nlm.nih.gov/pubmed/22081497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ibd.21929
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