The EIF4EBP3 translational repressor is a marker of CDC73 tumor suppressor haploinsufficiency in a parathyroid cancer syndrome

Germline mutation of the tumor suppressor gene CDC73 confers susceptibility to the hyperparathyroidism-jaw tumor syndrome associated with a high risk of parathyroid malignancy. Inactivating CDC73 mutations have also been implicated in sporadic parathyroid cancer, but are rare in sporadic benign para...

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Autors principals: Zhang, J-H, Seigneur, E M, Pandey, M, Loshakov, A, Dagur, P K, Connelly, P S, Koo, L, Panicker, L M, Simonds, W F
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288348/
https://ncbi.nlm.nih.gov/pubmed/22297294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.6
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