Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition

Glioblastoma multiforme (GBM) are resistant to TNFα-induced apoptosis and blockade of TNFα-induced NF-κB activation sensitizes glioma cells to apoptosis. As Casein kinase-2 (CK2) induces aberrant NF-κB activation and as we observed elevated CK2 levels in GBM tumors, we investigated the potential of...

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Bibliografiske detaljer
Main Authors: Dixit, D, Sharma, V, Ghosh, S, Mehta, V S, Sen, E
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288342/
https://ncbi.nlm.nih.gov/pubmed/22318540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.10
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