Interleukin-4 production by Follicular Helper T cells requires the conserved Il4 enhancer HS V

Follicular helper T cells (Tfh cells) are the major producers of interleukin-4 (IL-4) in secondary lymphoid organs where humoral immune responses develop. Il4 regulation in Tfh cells appears distinct from the classical T helper 2 (Th2) cell pathway, but the underlying molecular mechanisms remain lar...

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Main Authors: Vijayanand, Pandurangan, Seumois, Grégory, Simpson, Laura J., Abdul-Wajid, Sarah, Baumjohann, Dirk, Panduro, Marisella, Huang, Xiaozhu, Interlandi, Jeneen, Djuretic, Ivana M., Brown, Daniel R., Sharpe, Arlene H., Rao, Anjana, Ansel, K. Mark
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288297/
https://ncbi.nlm.nih.gov/pubmed/22326582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.12.014
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