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Regulation of paraoxonase 1 (PON1) in PCB 126-exposed male Sprague Dawley rats

3,3′,4,4′,5-Pentachlorobiphenyl (PCB 126), an aryl hydrocarbon receptor (AhR) agonist and most potent dioxin-like PCB congener, significantly alters gene expression, lipid metabolism, and oxidative stress in the liver. PON1, an antioxidant and anti-atherogenic enzyme, is produced in the liver and se...

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Autors principals: Shen, Hua, Robertson, Larry W., Ludewig, Gabriele
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288253/
https://ncbi.nlm.nih.gov/pubmed/22266287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2012.01.003
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