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Mechanisms of Loss of Functions of Human Angiogenin Variants Implicated in Amyotrophic Lateral Sclerosis

BACKGROUND: Mutations in the coding region of angiogenin (ANG) gene have been found in patients suffering from Amyotrophic Lateral Sclerosis (ALS). Neurodegeneration results from the loss of angiogenic ability of ANG (protein coded by ANG). In this work, we performed extensive molecular dynamics (MD...

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Bibliografiske detaljer
Main Authors: Padhi, Aditya K., Kumar, Hirdesh, Vasaikar, Suhas V., Jayaram, Bhyravabhotla, Gomes, James
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288110/
https://ncbi.nlm.nih.gov/pubmed/22384259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032479
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