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Stratify or adjust? Dealing with multiple populations when evaluating rare variants

The unrelated individuals sample from Genetic Analysis Workshop 17 consists of a small number of subjects from eight population samples and genetic data composed mostly of rare variants. We compare two simple approaches to collapsing rare variants within genes for their utility in identifying genes...

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Detalhes bibliográficos
Main Authors: Culverhouse, Robert C, Hinrichs, Anthony L, Suarez, Brian K
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287824/
https://ncbi.nlm.nih.gov/pubmed/22373399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1753-6561-5-S9-S101
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