A dynamic model of calcific nodule destabilization in response to monocyte- and oxidized lipid-induced matrix metalloproteinases

Vulnerable plaque remains clinically undetectable, and there is no accepted in vitro model. We characterize the calcific nodules produced by calcifying vascular cells (CVC) in ApoE-null mice, demonstrating increased destabilization of cultured nodules in the presence of oxidized low-density lipoprot...

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Autors principals: Li, Rongsong, Mittelstein, David, Lee, Juhyun, Fang, Karen, Majumdar, Rohit, Tintut, Yin, Demer, Linda L., Hsiai, Tzung K.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2012
Matèries:
Vascular Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287359/
https://ncbi.nlm.nih.gov/pubmed/22031601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00313.2011
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