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CCR7 mediates directed growth of melanomas towards lymphatics
OBJECTIVE: To determine whether chemotactic-metastasis, the preferential growth of melanomas towards areas of high lymphatic density, is CCL21/CCR7 dependent in vivo. Lymphatic endothelial cells (LECs) produce the chemokine CCL21. Metastatic melanoma cells express CCR7, its receptor, and exhibit che...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3287291/ https://ncbi.nlm.nih.gov/pubmed/21166932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1549-8719.2010.00074.x |
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