DNA-guided assembly of biosynthetic pathways promotes improved catalytic efficiency

Synthetic scaffolds that permit spatial and temporal organization of enzymes in living cells are a promising post-translational strategy for controlling the flow of information in both metabolic and signaling pathways. Here, we describe the use of plasmid DNA as a stable, robust and configurable sca...

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Main Authors: Conrado, Robert J., Wu, Gabriel C., Boock, Jason T., Xu, Hansen, Chen, Susan Y., Lebar, Tina, Turnšek, Jernej, Tomšič, Nejc, Avbelj, Monika, Gaber, Rok, Koprivnjak, Tomaž, Mori, Jerneja, Glavnik, Vesna, Vovk, Irena, Benčina, Mojca, Hodnik, Vesna, Anderluh, Gregor, Dueber, John E., Jerala, Roman, DeLisa, Matthew P.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2012
主題:
Synthetic Biology and Chemistry
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287197/
https://ncbi.nlm.nih.gov/pubmed/22021385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr888
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