RecA homology search is promoted by mechanical stress along the scanned duplex DNA

A RecA–single-stranded DNA (RecA–ssDNA) filament searches a genome for sequence homology by rapidly binding and unbinding double-stranded DNA (dsDNA) until homology is found. We demonstrate that pulling on the opposite termini (3′ and 5′) of one of the two DNA strands in a dsDNA molecule stabilizes...

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Bibliografiska uppgifter
Huvudupphovsmän: Danilowicz, Claudia, Feinstein, Efraim, Conover, Alyson, Coljee, Vincent W., Vlassakis, Julea, Chan, Yuen-Ling, Bishop, Douglas K., Prentiss, Mara
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2012
Ämnen:
Nucleic Acid Enzymes
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287184/
https://ncbi.nlm.nih.gov/pubmed/22013164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr855
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