Relief of autoinhibition of the electrogenic Na-HCO(3) cotransporter NBCe1-B: role of IRBIT vs. amino-terminal truncation

Two maneuvers known to stimulate electrogenic sodium bicarbonate cotransporter 1 (NBCe1) activity are 1) deletion from the cytosolic amino-terminus (Nt) of NBCe1-C of an 87-amino acid sequence that contains an autoinhibitory domain (AID); and 2) binding of the protein IRBIT to elements within the sa...

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Bibliographic Details
Main Authors: Lee, Seong-Ki, Boron, Walter F., Parker, Mark D.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2012
Subjects:
Membrane Transporters, Ion Channels and Pumps
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287159/
https://ncbi.nlm.nih.gov/pubmed/22012331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00352.2011
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