Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses

Homeobox 9 (HOXB9), a nontransforming transcription factor overexpressed in breast cancer, alters tumor cell fate and promotes tumor progression and metastasis. Here we show that HOXB9 confers resistance to ionizing radiation by promoting DNA damage response. In nonirradiated cells, HOXB9 induces sp...

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Detalhes bibliográficos
Main Authors: Chiba, Naokazu, Comaills, Valentine, Shiotani, Bunsyo, Takahashi, Fumiyuki, Shimada, Toshiyuki, Tajima, Ken, Winokur, Daniel, Hayashida, Tetsu, Willers, Henning, Brachtel, Elena, Vivanco, Maria d. M., Haber, Daniel A., Zou, Lee, Maheswaran, Shyamala
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Breast Cancer Special Feature
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286905/
https://ncbi.nlm.nih.gov/pubmed/21930940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018867108
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