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TLR4 dependent heparan sulphate-induced pancreatic inflammatory response is IRF3-mediated
BACKGROUND: Degraded extracellular matrix can stimulate the innate immune system via the Toll-Like Receptor-4 (TLR4). In the pancreas, syndecan-anchored heparan sulphate (HS) on the ductal epithelium can be cleaved off its protein cores by the proteases (trypsin and elastase) and potentially activat...
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| Hoofdauteurs: | , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
BioMed Central
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3286488/ https://ncbi.nlm.nih.gov/pubmed/22188870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-9-219 |
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