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An intrinsic BM hematopoietic niche occupancy defect of HSC in scid mice facilitates exogenous HSC engraftment

Although scid mice have been widely used for human HSC engraftment studies, the function of HSCs of scid mice has not been characterized. We hypothesized that the DNA repair defect of scid mice results in a stem cell defect that facilitates HSC engraftment. scid BM cells showed severely impaired rep...

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Autors principals: Qing, Yulan, Lin, Yuan, Gerson, Stanton L.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286352/
https://ncbi.nlm.nih.gov/pubmed/22147896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-05-350611
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