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Activation of IFN-beta element by IRF-1 requires a posttranslational event in addition to IRF-1 synthesis.
Expression of the Type I IFN (i.e., IFN-alpha s and IFN-beta) genes is efficiently induced by viruses at the transcriptional level. This induction is mediated by at least two types of positive regulatory elements located in the human IFN-beta gene promoter: (1) the repeated elements which bind both...
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| Hoofdauteurs: | , , , , |
|---|---|
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
1991
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| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC328629/ https://ncbi.nlm.nih.gov/pubmed/1886766 |
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