Mitochondrial dysfunction in ataxia-telangiectasia

Ataxia-telangiectasia mutated (ATM) plays a central role in DNA damage responses, and its loss leads to development of T-cell malignancies. Here, we show that ATM loss also leads to intrinsic mitochondrial abnormalities in thymocytes, including elevated reactive oxygen species, increased aberrant mi...

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Detalhes bibliográficos
Main Authors: Valentin-Vega, Yasmine A., MacLean, Kirsteen H., Tait-Mulder, Jacqueline, Milasta, Sandra, Steeves, Meredith, Dorsey, Frank C., Cleveland, John L., Green, Douglas R., Kastan, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286212/
https://ncbi.nlm.nih.gov/pubmed/22144182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-08-373639
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