Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus

Production of new neurons in the adult hippocampus decreases with age; this decline may underlie age-related cognitive impairment. Here we show that continuous depletion of the neural stem cell pool as a consequence of their division may contribute to the age-related decrease in hippocampal neurogen...

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Detalhes bibliográficos
Main Authors: Encinas, Juan M., Michurina, Tatyana V., Peunova, Natalia, Park, June-Hee, Tordo, Julie, Peterson, Daniel A., Fishell, Gord, Koulakov, Alex, Enikolopov, Grigori
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286186/
https://ncbi.nlm.nih.gov/pubmed/21549330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2011.03.010
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