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IGF-I Suppresses BMP Signaling in Prostate Cancer Cells by Activating mTOR Signaling
Insulin-like growth factor-I (IGF-I) and bone morphogenetic proteins (BMPs) are critical regulators of prostate tumor cell growth. In this report, we offer evidence that a critical support of IGF-I in prostate cancer is mediated by its ability to suppress BMP4-induced apoptosis and Smad-mediated gen...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3285447/ https://ncbi.nlm.nih.gov/pubmed/21062988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1119 |
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