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Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation
The prostate epithelial lineage hierarchy and the cellular origin for prostate cancer remain inadequately defined. Using a lineage tracing approach, we show that adult rodent prostate basal and luminal cells are independently self-sustained in vivo. Disrupting the tumor suppressor Pten in either lin...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3285423/ https://ncbi.nlm.nih.gov/pubmed/22340597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.01.005 |
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