Tumor Necrosis Factor (TNF) Receptor-associated Factor 7 Is Required for TNFα-induced Jun NH(2)-terminal Kinase Activation and Promotes Cell Death by Regulating Polyubiquitination and Lysosomal Degradation of c-FLIP Protein

The pro-inflammatory cytokine tumor necrosis factor (TNF) α signals both cell survival and death. The biological outcome of TNFα treatment is determined by the balance between survival factors and Jun NH(2)-terminal kinase (JNK) signaling, which promotes cell death. Here, we show that TRAF7, the mos...

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Detalhes bibliográficos
Main Authors: Scudiero, Ivan, Zotti, Tiziana, Ferravante, Angela, Vessichelli, Mariangela, Reale, Carla, Masone, Maria C., Leonardi, Antonio, Vito, Pasquale, Stilo, Romania
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285372/
https://ncbi.nlm.nih.gov/pubmed/22219201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.300137
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