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Implications of Cellular Senescence in Tissue Damage Response, Tumor Suppression, and Stem Cell Biology

Cellular senescence is characterized by an irreversible cell cycle arrest that, when bypassed by mutation, contributes to cellular immortalization. Activated oncogenes induce a hyperproliferative response, which might be one of the senescence cues. We have found that expression of such an oncogene,...

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Hlavní autoři: Krizhanovsky, V., Xue, W., Zender, L., Yon, M., Hernando, E., Lowe, S.W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285266/
https://ncbi.nlm.nih.gov/pubmed/19150958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/sqb.2008.73.048
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