Comparison of central versus peripheral delivery of pregabalin in neuropathic pain states

BACKGROUND: Although pregabalin therapy is beneficial for neuropathic pain (NeP) by targeting the CaVα(2)δ-1 subunit, its site of action is uncertain. Direct targeting of the central nervous system may be beneficial for the avoidance of systemic side effects. RESULTS: We used intranasal, intrathecal...

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Bibliografiske detaljer
Main Authors: Martinez, Jose A, Kasamatsu, Manami, Rosales-Hernandez, Alma, Hanson, Leah R, Frey, William H, Toth, Cory C
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285045/
https://ncbi.nlm.nih.gov/pubmed/22236461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-8-3
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