Therapeutic Trial of Metformin and Bortezomib in a Mouse Model of Tuberous Sclerosis Complex (TSC)

Tuberous sclerosis complex (TSC) is a human genetic disorder in which loss of either TSC1 or TSC2 leads to development of hamartoma lesions, which can progress and be life-threatening or fatal. The TSC1/TSC2 protein complex regulates the state of activation of mTORC1. Tsc2(+/−) mice develop renal cy...

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Bibliographic Details
Main Authors: Auricchio, Neil, Malinowska, Izabela, Shaw, Reuben, Manning, Brendan D., Kwiatkowski, David J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283697/
https://ncbi.nlm.nih.gov/pubmed/22363765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031900
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