TSC1/2 Signaling Complex Is Essential for Peripheral Naïve CD8(+) T Cell Survival and Homeostasis in Mice

The PI3K-Akt-mTOR pathway plays crucial roles in regulating both innate and adaptive immunity. However, the role of TSC1, a critical negative regulator of mTOR, in peripheral T cell homeostasis remains elusive. With T cell-specific Tsc1 conditional knockout (Tsc1 KO) mice, we found that peripheral n...

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Detalhes bibliográficos
Main Authors: Zhang, Lianjun, Zhang, Hongbing, Li, Lanlan, Xiao, Yi, Rao, Enyu, Miao, Zhuang, Chen, Hui, Sun, Lina, Li, Hongran, Liu, Guangwei, Zhao, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283604/
https://ncbi.nlm.nih.gov/pubmed/22363451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030592
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