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TSC1/2 Signaling Complex Is Essential for Peripheral Naïve CD8(+) T Cell Survival and Homeostasis in Mice
The PI3K-Akt-mTOR pathway plays crucial roles in regulating both innate and adaptive immunity. However, the role of TSC1, a critical negative regulator of mTOR, in peripheral T cell homeostasis remains elusive. With T cell-specific Tsc1 conditional knockout (Tsc1 KO) mice, we found that peripheral n...
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Main Authors: | , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Public Library of Science
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3283604/ https://ncbi.nlm.nih.gov/pubmed/22363451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030592 |
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