Loading...
Camptothecin cytotoxicity in mammalian cells is associated with the induction of persistent double strand breaks in replicating DNA.
Camptothecin is a specific topoisomerase I poison and is highly cytotoxic to eukaryotic cells. In the present study, we show, using a pulse field gel electrophoresis assay, that camptothecin induces DNA double strand breaks (DSBs) specifically in newly replicated DNA. Camptothecin induces these repl...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Artigo |
| Language: | Inglês |
| Published: |
1991
|
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC328325/ https://ncbi.nlm.nih.gov/pubmed/1905803 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|