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Nuclear Envelope Phosphatase 1-Regulatory Subunit 1 (Formerly TMEM188) Is the Metazoan Spo7p Ortholog and Functions in the Lipin Activation Pathway

Lipin-1 catalyzes the formation of diacylglycerol from phosphatidic acid. Lipin-1 mutations cause lipodystrophy in mice and acute myopathy in humans. It is heavily phosphorylated, and the yeast ortholog Pah1p becomes membrane-associated and active upon dephosphorylation by the Nem1p-Spo7p membrane c...

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Bibliografiske detaljer
Main Authors: Han, Sungwon, Bahmanyar, Shirin, Zhang, Peixiang, Grishin, Nick, Oegema, Karen, Crooke, Roseann, Graham, Mark, Reue, Karen, Dixon, Jack E., Goodman, Joel M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283218/
https://ncbi.nlm.nih.gov/pubmed/22134922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.324350
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