Antisense probes containing 2-aminoadenosine allow efficient depletion of U5 snRNP from HeLa splicing extracts.

RNA duplexes containing the modified base 2-amino-adenine in place of adenine are stabilized through the formation of three hydrogen bonds in 2-amino A.U base pairs. Antisense 2'-O-alkyloligoribonucleotide probes incorporating 2-aminoadenosine are thus able to efficiently affinity select RNP particl...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Lamm, G M, Blencowe, B J, Sproat, B S, Iribarren, A M, Ryder, U, Lamond, A I
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 1991
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC328310/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1648201/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/19.12.3193
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