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siRNA against presenilin 1 (PS1) down regulates amyloid β42 production in IMR-32 cells
BACKGROUND: One of the pathological hallmarks of Alzheimer's disease (AD) is the deposition of the ~4 kDa amyloid β protein (Aβ) within lesions known as senile plaques. Aβ is also deposited in the walls of cerebral blood vessels in many cases of AD. A substantial proportion of the Aβ that accum...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3282656/ https://ncbi.nlm.nih.gov/pubmed/22214483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-19-2 |
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