Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer

BACKGROUND: Activity of the tumour-suppressor gene PTEN is reduced in different types of cancer and implicates non-responsiveness to targeted therapy. This study evaluates the gene and protein status of PTEN in salivary gland carcinomas. METHODS: A total of 287 carcinomas of the major and minor sali...

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Detalhes bibliográficos
Main Authors: Ettl, T, Baader, K, Stiegler, C, Müller, M, Agaimy, A, Zenk, J, Kühnel, T, Gosau, M, Zeitler, K, Schwarz, S, Brockhoff, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282188/
https://ncbi.nlm.nih.gov/pubmed/22240798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.605
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