Large-Scale Analysis of Association Between LRP5 and LRP6 Variants and Osteoporosis

CONTEXT: Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population. OBJECTIVE: To generate large-scale evidence on whether...

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Autori principali: van Meurs, Joyce B. J., Trikalinos, Thomas A., Ralston, Stuart H., Balcells, Susana, Brandi, Maria Luisa, Brixen, Kim, Kiel, Douglas P., Langdahl, Bente L., Lips, Paul, Ljunggren, Östen, Lorenc, Roman, Obermayer-Pietsch, Barbara, Ohlsson, Claes, Pettersson, Ulrika, Reid, David M., Rousseau, Francois, Scollen, Serena, Van Hul, Wim, Agueda, Lidia, Åkesson, Kristina, Benevolenskaya, Lidia I., Ferrari, Serge L., Hallmans, Göran, Hofman, Albert, Husted, Lise Bjerre, Kruk, Marcin, Kaptoge, Stephen, Karasik, David, Karlsson, Magnus K., Lorentzon, Mattias, Masi, Laura, McGuigan, Fiona E. A., Mellström, Dan, Mosekilde, Leif, Nogues, Xavier, Pols, Huibert A. P., Reeve, Jonathan, Renner, Wilfried, Rivadeneira, Fernando, van Schoor, Natasja M., Weber, Kurt, Ioannidis, John P. A., Uitterlinden, André G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282142/
https://ncbi.nlm.nih.gov/pubmed/18349089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.299.11.1277
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