Neonatal Periostin Knockout Mice Are Protected from Hyperoxia-Induced Alveolar Simplication

In bronchopulmonary dysplasia (BPD), alveolar septae are thickened with collagen and α-smooth muscle actin, transforming growth factor (TGF)-β-positive myofibroblasts. Periostin, a secreted extracellular matrix protein, is involved in TGF-β-mediated fibrosis and myofibroblast differentiation. We hyp...

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Main Authors: Bozyk, Paul D., Bentley, J. Kelley, Popova, Antonia P., Anyanwu, Anuli C., Linn, Marisa D., Goldsmith, Adam M., Pryhuber, Gloria S., Moore, Bethany B., Hershenson, Marc B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281961/
https://ncbi.nlm.nih.gov/pubmed/22363622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031336
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