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Rate limiting P-O(5') bond cleavage of RNA fragment: ab initio molecular orbital calculations on the base-catalyzed hydrolysis of phosphate.

In order to examine the energetics in base-catalyzed hydrolysis of RNA, a tentative pentacoordinated intermediate (3) has been characterized by molecular orbital calculations. Ab initio studies at the level of 3-21G* indicate that, under the Cs symmetry restricted conditions, the P-O(2) bond possess...

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Xehetasun bibliografikoak
Egile Nagusiak: Taira, K, Uchimaru, T, Tanabe, K, Uebayasi, M, Nishikawa, S
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1991
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC328196/
https://ncbi.nlm.nih.gov/pubmed/1710344
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