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Calpain-mediated Processing of p53-associated Parkin-like Cytoplasmic Protein (PARC) Affects Chemosensitivity of Human Ovarian Cancer Cells by Promoting p53 Subcellular Trafficking

Resistance to cisplatin (CDDP)-based therapy is a major hurdle to the successful treatment of human ovarian cancer (OVCA), and the chemoresistant phenotype in OVCA cells is associated with Akt-attenuated p53-mediated apoptosis. Pro-apoptotic functions of p53 involve both transcription-dependent and...

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Sonraí Bibleagrafaíochta
Main Authors: Woo, Michael G., Xue, Kai, Liu, Jiayin, McBride, Heidi, Tsang, Benjamin K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281727/
https://ncbi.nlm.nih.gov/pubmed/22117079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.314765
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