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Loss-of-Function Mutations in the KCNJ8-Encoded Kir6.1 K(ATP) Channel and Sudden Infant Death Syndrome

BACKGROUND: Approximately 10% of sudden infant death syndrome (SIDS) may stem from cardiac channelopathies. The KCNJ8-encoded Kir6.1 (K(ATP)) channel critically regulates vascular tone and cardiac adaptive response to systemic metabolic stressors, including sepsis. KCNJ8-deficient mice are prone to...

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Bibliografske podrobnosti
Main Authors: Tester, David J., Tan, Bi-Hua, Medeiros-Domingo, Argelia, Song, Chunhua, Makielski, Jonathan C., Ackerman, Michael J.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281577/
https://ncbi.nlm.nih.gov/pubmed/21836131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.111.960195
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