A Biphasic and Brain-Region Selective Down-Regulation of Cyclic Adenosine Monophosphate Concentrations Supports Object Recognition in the Rat

BACKGROUND: We aimed to further understand the relationship between cAMP concentration and mnesic performance. METHODS AND FINDINGS: Rats were injected with milrinone (PDE3 inhibitor, 0.3 mg/kg, i.p.), rolipram (PDE4 inhibitor, 0.3 mg/kg, i.p.) and/or the selective 5-HT4R agonist RS 67333 (1 mg/kg,...

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Detalhes bibliográficos
Main Authors: Hotte, Maïte, Dauphin, François, Freret, Thomas, Boulouard, Michel, Levallet, Guenaëlle
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281138/
https://ncbi.nlm.nih.gov/pubmed/22359674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032244
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