Altered Bone Development and an Increase in FGF-23 Expression in Enpp1(−/−) Mice

Nucleotide pyrophosphatase phosphodiesterase 1 (NPP1) is required for the conversion of extracellular ATP into inorganic pyrophosphate (PP(i)), a recognised inhibitor of hydroxyapatite (HA) crystal formation. A detailed phenotypic assessment of a mouse model lacking NPP1 (Enpp1(−/−)) was completed t...

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Bibliographic Details
Main Authors: Mackenzie, Neil Charles Wallace, Zhu, Dongxing, Milne, Elspeth M., van 't Hof, Rob, Martin, Aline, Quarles, Darryl Leigh, Millán, José Luis, Farquharson, Colin, MacRae, Vicky Elisabeth
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281127/
https://ncbi.nlm.nih.gov/pubmed/22359666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032177
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