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Physical properties of oligonucleotides containing phosphoramidate-modified internucleoside linkages.
Because of their nuclease resistance and ability to form substrates for RNase H, antisense oligodeoxynucleotides (ODNs) possessing several methoxyethylphosphoramidate linkages at both termini have proven effective at targeting the degradation of specific mRNAs in Xenopus embryos. The efficacy of the...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
1991
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| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC328108/ https://ncbi.nlm.nih.gov/pubmed/2030962 |
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