Genome-Wide RNAi Screen in IFN-γ-Treated Human Macrophages Identifies Genes Mediating Resistance to the Intracellular Pathogen Francisella tularensis

Interferon-gamma (IFN-γ) inhibits intracellular replication of Francisella tularensis in human monocyte-derived macrophages (HMDM) and in mice, but the mechanisms of this protective effect are poorly characterized. We used genome-wide RNA interference (RNAi) screening in the human macrophage cell li...

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Detalhes bibliográficos
Main Authors: Zhou, Hongwei, DeLoid, Glen, Browning, Erica, Gregory, David J., Tan, Fengxiao, Bedugnis, Alice S., Imrich, Amy, Koziel, Henry, Kramnik, Igor, Lu, Quan, Kobzik, Lester
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281001/
https://ncbi.nlm.nih.gov/pubmed/22359626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031752
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