On the Effect of Thermodynamic Equilibrium on the Assembly Efficiency of Complex Multi-Layered Virus-Like Particles (VLP): the Case of Rotavirus VLP

Previous studies have reported the production of malformed virus-like-particles (VLP) in recombinant host systems. Here we computationally investigate the case of a large triple-layered rotavirus VLP (RLP). In vitro assembly, disassembly and reassembly data provides strong evidence of microscopic re...

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Autors principals: Roldão, António, Mellado, Maria Candida M., Lima, J. C., Carrondo, Manuel J. T., Alves, Paula M., Oliveira, R.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280969/
https://ncbi.nlm.nih.gov/pubmed/22359487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002367
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