Self-reactive human CD4 T cell clones form unusual immunological synapses

Recognition of self–peptide-MHC (pMHC) complexes by CD4 T cells plays an important role in the pathogenesis of many autoimmune diseases. We analyzed formation of immunological synapses (IS) in self-reactive T cell clones from patients with multiple sclerosis and type 1 diabetes. All self-reactive T...

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Detalhes bibliográficos
Main Authors: Schubert, David A., Gordo, Susana, Sabatino, Joseph J., Vardhana, Santosh, Gagnon, Etienne, Sethi, Dhruv K., Seth, Nilufer P., Choudhuri, Kaushik, Reijonen, Helena, Nepom, Gerald T., Evavold, Brian D., Dustin, Michael L., Wucherpfennig, Kai W.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280872/
https://ncbi.nlm.nih.gov/pubmed/22312112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111485
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