Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases

Metaplasticity is a higher form of synaptic plasticity that is essential for learning and memory, but its molecular mechanisms remain poorly understood. Here, we report that metaplasticity of transmission at CA1 synapses in the hippocampus is mediated by Src family kinase regulation of NMDA receptor...

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Detalhes bibliográficos
Main Authors: Yang, Kai, Trepanier, Catherine, Sidhu, Bikram, Xie, Yu-Feng, Li, Hongbin, Lei, Gang, Salter, Michael W, Orser, Beverley A, Nakazawa, Takanobu, Yamamoto, Tadashi, Jackson, Michael F, MacDonald, John F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280552/
https://ncbi.nlm.nih.gov/pubmed/22187052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.453
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